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Цитата:
1.1.5 Pentoxifylline
Pentoxifylline is a weak antithrombotic agent; its putative mechanisms of action include an increase in RBC deformity, and decreases in fibrinogen concentration, platelet adhesiveness, and whole-blood viscosity.One metaanalysis suggests that pentoxifylline improves walking distance by 29 m compared with placebo, although the improvement was approximately 50% in the placebo group, and use of pentoxifylline improved walking distance by an additional 30%. Moreover, clinical trials have shown conflicting results. Some have concluded that pentoxifylline was significantly more effective than placebo in improving treadmill-walking distance, but others could not demonstrate consistent benefit. In many trials, patients treated with placebo also demonstrated significant improvement. Thus, the actual improvement in walking distance attributable to pentoxifylline is often unpredictable and may not be clinically important compared with the effects of placebo. In summary, the evidence for a beneficial effect of pentoxifylline is not strong enough to suggest an important role in the treatment of patients with PAOD.
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Цитата:
We recommend againstthe use of pentoxifylline (Grade 1B).
Сейчас некогда прилично перевести, но смысл вроде ясен. Не очень он эффективен. Дальность безболевой хотьбы, по крайней мере, не увеличивает.
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