В PubMed обнаружено 28 ссылок на препарат Padma 28, который с успехом применяется в Тибетской Медицине, более 40 лет в Западной Европе, но незнаком российским врачам
Вот свежие резюме.
Atherosclerosis. 2006 Apr 3.
Treating intermittent claudication with Tibetan medicine Padma 28: Does it work?
Melzer J, Brignoli R, Diehm C, Reichling J, Do DD, Saller R.
Department of Internal Medicine, Complementary Medicine, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Herbal drugs are being increasingly used in medical practice, often without appropriate scrutiny of their safety and efficacy. The medicinal product Padma 28 is a fixed combination with Tibetan origin, used in Europe since the 1960s for the symptomatic treatment of circulatory disorders, including those of peripheral arterial occlusive disease (PAOD). We have conducted an analysis of all available data on this herbal drug from published literature as well as from original data we obtained from contacting the authors of published papers, reports and the manufacturer. A total of 19 trials have reported on 2084 patients to date, 444 of whom were in six controlled clinical studies on PAOD. A meta-analysis of five trials showed Padma 28 to increase walking distance by >100m in 18.2% of the patients with verum, versus 2.1% with placebo (P<0.001; odds ratio: 10 [95% CI 3.03, 33.33]; RR: 0.12; number needed to treat=6.2). The safety profile appears to be favourable. Available evidence shows that Padma 28 provides significant relief from PAOD-related symptoms (i.e. walking distance), probably of the same order of magnitude as other employed medications. However, larger confirmatory RCTs are desirable.
Forsch Komplementarmed. 2006 Feb;13 Suppl 1:7-12. Epub 2006 Feb
Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall.
Ueberall F, Fuchs D, Vennos C.
Division of Medical Biochemistry, Biocenter, Innsbruck Medical School, Osterreich.
florian.ueberall@i-med.ac.at
BACKGROUND: The Tibetan remedy Padma 28 has been used in Europe for decades and has proved to be effective in inflammatory and atherosclerotic conditions. Beyond clinical trials, a large number of in vitro and ex vivo studies report various properties and biochemical activities of this complex herbal multicompound. OBJECTIVE: To give an overview of the complex efficacy profile of Padma 28, to review available data, to relate findings to the development of atherosclerosis and thus to discuss the antiatherogenic potential of Padma 28. METHODS: Published non-clinical original papers on Padma 28 were collected and classified according to the studied mechanisms of action. Results were correlated to the briefly described sequences of atherogenesis and various mechanisms of action were elaborated, laying particular emphasis on more recent articles. RESULTS: The complex activity profile of Padma 28 spans mainly direct and indirect anti-inflammatory proper-ties as well as further categories of biochemical actions. These can be related to the complex processes of atherogenesis. CONCLUSIONS: The described mechanisms support the therapeutic field of application of Padma 28, i.e. peripheral circulatory disorders as well as chronic inflammatory disorders. Moreover, the numerous effects as well as the diversity of sites of action allow to draw first conclusions on the conceptual design of this multicomponent formula.
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